Key result
Increased wall shear stress induces endothelial surface roughening and spindle-shaped swellings in carotid arteries.
Why the study?
The morphological changes in the endothelial surface of arteries due to wall shear stress load were not well characterized.
Population
7 dogs with arterio-venous shunt between common carotid artery and external jugular vein
Comparison
Shunted artery with increased flow ratio fs/fc versus ipsi-lateral control artery
Design
Experimental study with scanning electron microscopy analysis
Follow-up
1 week postoperatively
Authors
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Endothelial changes under high shear stress require human validation; leaves open relevance to atherosclerosis.
Kamiya et al. (1982) studied Endothelial surface changes due to wall shear stress (n=7). Arterio-venous shunt (increased wall shear stress load) vs. Ipsi-lateral control artery was evaluated on Ultrastructural changes in the endothelial surface. Increased wall shear stress load induced by an arterio-venous shunt resulted in rough endothelial surfaces with spindle-shaped swellings and fine transverse wrinkles in the canine carotid artery.
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