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March 1, 1986Arteriosclerosis An Official Journal of the American Heart Association Inc

Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta.

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Population

Dogs with experimentally induced aortic stenosis (71% reduction of cross-sectional area)

Comparison

Creation of aortic stenosis vs Different hemodynamic regions within the same…

Design

Preclinical

Follow-up

12 weeks

Authors

MLM. J. LevesqueDLD. LiepschSMS. Moravec

Discussion

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Overview

Does not inform clinical practice; leaves open hemodynamic effects on endothelium in human atherosclerosis.

Structured PICO

P
Population
Dogs with experimentally induced aortic stenosis (71% reduction of cross-sectional area)
I
Intervention
Creation of aortic stenosis (71% reduction of cross-sectional area)
C
Comparator
Different hemodynamic regions within the same vessel (prestenotic vs. convergent vs. divergent regions)
O
Outcome
Endothelial cell geometry (area and shape index) and its correlation with local wall shear stresssurrogate

This study demonstrates that endothelial cell shape is directly influenced by local hemodynamic forces, specifically wall shear stress, in an in vivo stenosed aorta model.

Cite This Study

Levesque et al. (1986) studied this question.

synapsesocial.com/papers/6a209501f796ac642d951126https://doi.org/10.1161/01.atv.6.2.220
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