Key result
Endothelial cells exposed to spatial wall shear stress gradients exhibited a randomly oriented, cobblestone shape compared to the spindle-like shape seen in uniform flow regions.
Population
Human abdominal aortic endothelial cells
Comparison
Exposure to steady flow (Re=50, 100, and 200 and… vs Straight/tubular in vitro models and static…
Design
Preclinical
Authors
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May promote endothelial permeability in disturbed flow; hypothesis-generating for plaque instability mechanisms.
Endothelial cells exposed to spatial wall shear stress gradients in an asymmetric stenosis model exhibit a cobblestone morphology, which may increase permeability and prothrombotic factor expression, potentially explaining plaque instability.
Rouleau et al. (2010) studied Atherosclerosis. Spatial wall shear stress gradients (asymmetric stenosis model) vs. Straight/tubular models (uniform wall shear stress) and static controls was evaluated on Local morphological changes (cell alignment and shape). Endothelial cells exposed to spatial wall shear stress gradients exhibited a randomly oriented, cobblestone shape compared to the spindle-like shape seen in uniform flow regions.
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