Population
Aortic tissue specimens (in vivo) and porcine aortic endothelial cells (in vitro)
Comparison
Fluid-imposed shear stress vs No-flow conditions; non-coated glass coverslips
Design
Preclinical
Follow-up
24 hours (in vitro)
Authors
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Does not support clinical translation; leaves open ECM modulation of endothelial remodeling in vivo.
Fluid-imposed shear stress induces rapid cytoskeletal rearrangement and shape changes in vascular endothelial cells, which are modulated by extracellular matrix anchorage.
Sato et al. (1994) studied this question.
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