December 6, 2001Clinical and Experimental Pharmacology and Physiology
Local Pulse Pressure Is A Major Determinant Of Large Artery Remodelling
Why the study?
Does local pulse pressure determine large artery remodelling more strongly than mean blood pressure?
Population
Normotensive individuals, patients with essential hypertension, and patients with Marfan syndrome
Design
Review
Authors
Discussion
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Member takes
Implication
May prioritize local pulse pressure in carotid assessment over mean pressure; leaves open causal and therapeutic implications.
Structured PICO
Does local pulse pressure determine large artery remodelling more strongly than mean blood pressure?
P
Population
Normotensive individuals, patients with essential hypertension, and patients with Marfan syndrome
O
Outcome
Large artery remodelling (intima-media thickness and internal diameter)surrogate
Local pulse pressure is a stronger determinant of large artery remodeling (such as carotid intima-media thickness and internal diameter) than mean blood pressure, which may explain its predictive value for cardiovascular events.
Cite This Study
Laurent et al. (2001) studied this question.