Key Points
- To examine the multidimensional determinants of escalating cardiovascular disease burdens in developing regions and define strategic public health responses.
- Analyzed the effects of demographic aging, urbanization, industrialization, and globalization on disease patterns.
- Evaluated developmental and biological risk mechanisms, including fetal undernutrition, gene-environment interactions, diet, physical activity, and tobacco use.
- Cardiovascular disease burdens are accelerating across developing nations driven by altered population age structures, shifting dietary habits, sedentary lifestyles, and tobacco consumption.
- Early-life biological influences, particularly fetal undernutrition, alongside gene-environment dynamics, heighten adult susceptibility to vascular disorders.
- Mitigating the epidemic requires integrating primordial, primary, and secondary prevention through community-level interventions, nutrition-based policies, and multisectoral health coalitions.
Structured PICO
PPopulationPopulations in developing countries experiencing rapid health transition
Highlights the urgent need for comprehensive public health responses, including primordial, primary, and secondary prevention, to combat the escalating CVD epidemic in developing countries.