What question did this study set out to answer?

To review evidence that the cystic fibrosis transmembrane conductance regulator operates as a regulator of other membrane proteins and ion channels in addition to acting as an intrinsic chloride channel.

January 1, 1999Physiological Reviews

CFTR Is a Conductance Regulator as well as a Chloride Channel

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Authors

ESErik M. SchwiebertGeorgia Institute of Technology DBDale BenosBoston University MEMarie E. EganYale University

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Implication

Literature review demonstrates CFTR regulation of diverse ion channels in epithelial membranes, indicating broader functional roles beyond chloride transport.

Key Points

To review evidence that the cystic fibrosis transmembrane conductance regulator operates as a regulator of other membrane proteins and ion channels in addition to acting as an intrinsic chloride channel.
Narrative synthesis of physiological and biochemical studies evaluating CFTR structure and transport mechanisms within the ATP-binding cassette (ABC) transporter family.
Comparative analysis of ABC transporter homologs, including mdr-1 and SUR, to examine conserved mechanisms of ion channel and protein regulation.
CFTR intrinsically conducts chloride at high rates while retaining the nonconductive transport architecture characteristic of ABC family transporters.
CFTR modulates the activity and conductance of separate ion channel proteins across the plasma membrane, mirroring regulatory functions seen in mdr-1 and SUR.

Cite This Study

Schwiebert et al. (1999) studied this question.

synapsesocial.com/papers/6a1051ae5725bbd5cc60d72f https://doi.org/10.1152/physrev.1999.79.1.s145

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Implication

Literature review demonstrates CFTR regulation of diverse ion channels in epithelial membranes, indicating broader functional roles beyond chloride transport.

CFTR Is a Conductance Regulator as well as a Chloride Channel

Discussion

Member takes

Implication

Key Points

Cite This Study

CFTR Is a Conductance Regulator as well as a Chloride Channel

Discussion

Member takes

Implication

Key Points

Cite This Study

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