Why the study?
Are there gender differences in clinical presentation, risk factors, and outcomes among patients with acute stroke?
Are there gender differences in clinical presentation, risk factors, and outcomes among patients with acute stroke?
In a Turkish stroke registry, female gender was associated with older age, different risk factor profiles (more atrial fibrillation and hypertension), and independently predicted poor in-hospital outcomes in ischemic stroke.
May inform prognosis discussions for women with ischemic stroke; leaves open need for prospective validation before practice change.
BACKGROUND: We aimed to investigate gender differences in Turkish stroke patients. MATERIAL AND METHODS: Demographics, risk factors, clinical and etiologic subtypes, laboratory findings, clinical course, and in-hospital prognosis of 1 522 patients with ischemic stroke (IS) and 320 patients with intracerebral hemorrhage prospectively registered in the Istanbul Medical School Stroke Registry (1994-2004) were analyzed separately. RESULTS: The mean age of IS patients was higher in females (n : 751) (P<0.0001). In males, smoking, ischemic heart disease, peripheral arterial disease, posterior circulation syndromes, and strokes due to large-artery atherosclerosis were more common (P<0.0001 for each). Prestroke disability, atrial fibrillation (P<0.0001), hypertension (P=0.041), modified Rankin Scale (mRS) 3-5 at admission (P<0.0001), total anterior circulation syndrome (P<0.0001), and cardioembolic stroke (P<0.0001) were more frequent in females. Female gender was an independent predictor of poor outcome (mRS 3-6). CONCLUSION: Gender differences were observed exclusively in patients with IS. Although our patients were younger than those reported, gender differences were similar.
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Yeşilot et al. (2011) studied this question.
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