Why the study?
Does intracoronary BQ-123 prevent the normal reduction of myocardial ischemia on repeated balloon inflations during angioplasty in patients undergoing coronary angioplasty?
Population
80 patients undergoing coronary angiography or angioplasty
Comparison
Intracoronary infusion of BQ-123 (selective ET… vs Intracoronary infusion of saline
Design
RCT, randomly allocated
Follow-up
Acute (during procedure)
Authors
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BQ-123 blunts ischemic preconditioning during PCI; challenges ET(A) antagonism for periprocedural protection and leaves clinical outcomes open.
Does intracoronary BQ-123 prevent the normal reduction of myocardial ischemia on repeated balloon inflations during angioplasty in patients undergoing coronary angioplasty?
Acute ET(A) receptor antagonism with BQ-123 prevents the normal ischemic preconditioning-like reduction of myocardial ischemia during repeated balloon inflations, possibly due to a coronary collateral steal effect.
Kyriakides et al. (2000) studied this question.
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