The phase diagram data of 60 binary systems of drugs were evaluated with the aid of a computer-coupled phase diagram/thermodynamic analysis. Data for this analysis were obtained by an exhaustive literature search (110 references). Among the results of this analysis are the excess Gibbs energy of liquid and solid solution phases, and the thermodynamic properties of intermediate compounds. For each system a phase diagram was calculated; such calculated diagrams are thermodynamically consistent and are offered as the best constructions which can be deduced from available data.
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James Sangster (1999) studied this question.