Key result
Bradykinin may mediate the effects of ACE inhibitors on endothelial function, ischemic hearts, cardiac hypertrophy, and myocardial capillary growth via paracrine-autocrine mechanisms.
ACE inhibitors may exert beneficial effects on cardiac structure and function, such as myocardial capillary growth, partly through the prevention of bradykinin degradation.
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May support bradykinin-focused ACE inhibitor optimization; leaves open prospective trials to confirm paracrine effects.
Tschöpe et al. (1994) conducted a review in Hypertension / Cardiac hypertrophy / Ischaemic heart disease. ACE inhibitors / Bradykinin was evaluated. Bradykinin may mediate the effects of ACE inhibitors on endothelial function, ischemic hearts, cardiac hypertrophy, and myocardial capillary growth via paracrine-autocrine mechanisms.
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