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May 3, 2018BloodOpen Access

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Sanjay S. Patel Frank C. Kuo Christopher J. Gibson David P. Steensma Robert J. Soiffer Edwin P. Alyea Yi-Bin A. Chen Amir T. Fathi Timothy A. Graubert Andrew M. Brunner Martha Wadleigh Richard M. Stone Daniel J. DeAngelo Valentina Nardi Robert P. Hasserjian Olga K. Weinberg

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Abstract

Key Points High NPM1-mutant allele burden at diagnosis is associated with poor clinical outcome in de novo AML. The adverse effect of high NPM1-mutant allele burden is independent of comutations and clinical variables.

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Patel et al. (2018) studied this question.

synapsesocial.com/papers/6a106a1fb6f5ee040160a46f https://doi.org/10.1182/blood-2018-01-828467

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