Key result
A 1-SD increase in neuroticism was associated with a 12% increased risk of cardiovascular disease mortality (HR 1.12; 95% CI 1.03-1.21), but not all-cause mortality after full adjustment.
Why the study?
Does neuroticism or extraversion influence all-cause and cause-specific mortality in adults?
Population
5,424 adults from the British nationwide Health and Lifestyle Survey with complete data
Design
Cohort
Follow-up
21 years
Authors
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Neuroticism may inform CVD risk stratification in observational cohorts; leaves open causality and any practice change.
Cohort (n=9,003)
Yes
Does neuroticism or extraversion influence all-cause and cause-specific mortality in adults?
Effect estimate: HR 1.05 (95% CI 0.99-1.11)
High neuroticism is significantly related to an increased risk of death from cardiovascular disease over 21 years, potentially mediated by sociodemographic, health behavior, and physiological factors.
Shipley et al. (2007) conducted a cohort in Mortality (n=9,003). Neuroticism was evaluated on All-cause mortality (fully adjusted) (HR 1.05, 95% CI 0.99-1.11). A 1-SD increase in neuroticism was associated with a 12% increased risk of cardiovascular disease mortality (HR 1.12; 95% CI 1.03-1.21), but not all-cause mortality after full adjustment.
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