Key result
Recalibration using freshly collected human sera in a regional standardization program resulted in all 12 participating laboratories achieving a mean HDL cholesterol bias ≤5%.
Why the study?
Does the use of freshly collected, never-frozen human sera improve the interlaboratory standardization and accuracy of lipid profile assays compared to frozen sera?
Population
12 clinical laboratories participating in a lipid standardization program initiated by the Clinical…
Comparison
Recalibration and standardization of lipid… vs Pools of frozen human sera
Design
Other
Authors
Loading...
Supports regional HDL standardization with fresh sera; leaves open effects on clinical lipid assay accuracy.
Observational
Yes
Does the use of freshly collected, never-frozen human sera improve the interlaboratory standardization and accuracy of lipid profile assays compared to frozen sera?
Freshly collected, never-frozen human sera are necessary for accurate interlaboratory standardization of lipid profiles, as frozen sera introduce significant matrix biases.
Tetrault et al. (1990) conducted an observational in Lipid testing accuracy. Recalibration using freshly collected human sera vs. Frozen human sera was evaluated on Mean HDL cholesterol and triglycerides bias. Recalibration using freshly collected human sera in a regional standardization program resulted in all 12 participating laboratories achieving a mean HDL cholesterol bias ≤5%.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: