What question did this study set out to answer?

To compare the long-term clinical outcomes, radiotherapeutic responses, and progression rates to multiple myeloma between solitary plasmacytoma of bone and extramedullary plasmacytoma.

March 1, 1979CancerOpen Access

Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma

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Authors

JCJames CorwinTufts Medical Center RLRobert D. LindbergLeiden University Medical Center

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Implication

Retrospective review reveals superior long-term disease-free survival in extramedullary plasmacytoma compared to solitary bone plasmacytoma, highlighting distinct clinical courses.

Key Points

To compare the long-term clinical outcomes, radiotherapeutic responses, and progression rates to multiple myeloma between solitary plasmacytoma of bone and extramedullary plasmacytoma.
Retrospective review of 24 patients (N=12 with solitary plasmacytoma of bone [SPB] and N=12 with extramedullary plasmacytoma [EMPC]) treated with radiotherapy between 1948 and 1977 at M. D. Anderson Hospital.
Patients received radiation doses primarily exceeding 4,000 rads at 200 rads per day (22/24 patients), with a minimum 3-year disease-free interval required for solitary classification.
Disease-free survival was higher in EMPC, with 8 of 11 patients showing no evidence of disease (NED) at 3 and 5 years and 6 of 9 at 10 years, compared to SPB with 5 of 9 NED at 3 years, 4 of 5 at 5 years, and 0 of 4 at 10 years.
Progression to multiple myeloma occurred in 6 of 12 patients with SPB compared to 2 of 12 patients with EMPC, confirming a more favorable prognosis for EMPC.

Cite This Study

Corwin et al. (1979) studied this question.

synapsesocial.com/papers/6a1075384fb650da4fff7dac https://doi.org/10.1002/1097-0142(197903)43:3<1007::aid-cncr2820430333>3.0.co;2-4

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Implication

Retrospective review reveals superior long-term disease-free survival in extramedullary plasmacytoma compared to solitary bone plasmacytoma, highlighting distinct clinical courses.

Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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