High density lipoprotein cholesterol is not a major risk factor for ischaemic heart disease in British men.
Key result
HDL cholesterol was not a significant independent predictor of major ischaemic heart disease after adjustment, whereas men in the highest fifth of non-HDL cholesterol had over 3 times the risk.
Why the study?
Is HDL cholesterol concentration an independent risk factor for major ischaemic heart disease in middle-aged British men?
Population
7,415 men aged 40-59 drawn from general practices in 24 British towns
Design
Cohort
Follow-up
average 4.2 years
Authors
Discussion
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Member takes
Implication
May de-emphasize HDL in ischaemic heart disease risk assessment for middle-aged men; extends evidence prioritizing non-HDL cholesterol in observational cohorts.
Key Points
- This research aims to examine whether high density lipoprotein cholesterol (HDL cholesterol) is a significant risk factor for ischaemic heart disease in British men.
- Measured HDL and total cholesterol levels in a prospective cohort of men aged 40-59 from 24 British towns.
- Followed up participants for an average of 4.2 years and registered cases of major ischaemic heart disease.
- Used multivariate analysis to compare the predictive power of HDL cholesterol and non-HDL cholesterol.
- 193 cases of ischaemic heart disease were registered among 7415 men.
- Men with ischaemic heart disease had lower HDL cholesterol, but the difference was not significant when adjusting for other risk factors.
- Non-HDL cholesterol was a stronger predictor of ischaemic heart disease risk, with the highest fifth having over three times the risk compared to the lowest fifth.
Study Design
Type
Cohort (n=7,415)
Multicenter
Yes
Structured PICO
Is HDL cholesterol concentration an independent risk factor for major ischaemic heart disease in middle-aged British men?
P
Population
7,415 men aged 40-59 drawn from general practices in 24 British towns
I
Intervention
Serum HDL cholesterol and total cholesterol concentration measurement
O
Outcome
Major ischaemic heart diseasehard clinical
Non-HDL cholesterol is a more powerful predictor of ischaemic heart disease risk than HDL cholesterol, which loses significance after adjusting for other risk factors.
Cite This Study
Pocock et al. (1986) conducted a cohort in Ischaemic heart disease (n=7,415). HDL cholesterol vs. Non-HDL cholesterol was evaluated on Major ischaemic heart disease. HDL cholesterol was not a significant independent predictor of major ischaemic heart disease after adjustment, whereas men in the highest fifth of non-HDL cholesterol had over 3 times the risk.