Key result
Elevated hs-CRP linked to ~106% higher cognitive impairment risk in normal-weight but not overweight patients.
Why the study?
The study was conducted to determine the association of overweight and high-sensitivity C-reactive protein with the odds of cognitive impairment and its subtypes in a Chinese community-based population.
Is there an association between elevated hs-CRP levels, overweight status, and cognitive impairment in Chinese adults?
Cross-Sectional (n=3,875)
Is there an association between elevated hs-CRP levels, overweight status, and cognitive impairment in Chinese adults?
Effect estimate: OR 2.06 (95% CI 1.03-4.10)
Absolute Event Rate: 8.42% vs 4.24%
p-value: p=0.04
Elevated hs-CRP is associated with increased odds of cognitive impairment in normal-weight, but not overweight, Chinese adults.
Elevated hs-CRP was associated with cognitive impairment only in normal-weight adults; hypothesis-generating and requires longitudinal confirmation before clinical consideration.
Purpose: To determine the association between overweight and high-sensitivity C-reactive protein (hs-CRP) with the odds of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China. Materials and methods: We conducted a cross-sectional analysis of the follow-up data of 2012 from the APAC study. The Chinese version of the MMSE was used as a cognitive screener, and an MMSE score <24 is generally accepted as indicating cognitive impairment. Multivariable logistic regression was used to estimate the interactions of hs-CRP levels with body mass index (BMI) on the effects of cognitive impairment and its subtypes. Results: Three thousand eight hundred seventy-five participants aged 40–90 years (median age 51.64 y) were enrolled in this study, and 1,788 (46.1%) were overweight. Before and after adjusting for confounders, such as age, sex, BMI, education, current smoking, drinking, physical activity, hypertension, hyperlipidemia, diabetes, and hs-CRP, elevated hs-CRP levels were associated with cognitive impairment in normal-weight participants (crude OR: 2.08, 95%CI: 1.28–3.37, p = 0.003; adjusted OR: 2.06, 95%CI: 1.03–4.10, p = 0.04), but not in overweight participants. There was no statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-item. Conclusion: Elevated hs-CRP levels increase the odds of cognitive impairment in normal-weight participants, but not in overweight participants.
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Wang et al. (2020) conducted a cross-sectional in Cognitive impairment (n=3,875). Elevated hs-CRP (≥3 mg/L) vs. Low-medium hs-CRP (<3 mg/L) was evaluated on Cognitive impairment (MMSE score < 24) in normal-weight participants (OR 2.06, 95% CI 1.03-4.10, p=0.04). Elevated hs-CRP levels increased the odds of cognitive impairment (adjusted OR 2.06) in normal-weight participants, but not in overweight participants.
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