July 15, 2010Journal of Applied PhysiologyOpen Access

Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans

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Why the study?

Does blockade of group III and IV muscle afferents with intrathecal fentanyl alter the ventilatory and cardiovascular responses to rhythmic exercise in healthy humans?

Population

7 moderately trained male cyclists, mean age 23.9 ± 3.6 years, body mass 74.0 ± 8.3 kg, maximal O2…

Comparison

Lumbar intrathecal fentanyl injected at the… vs Placebo prior to identical exercise.

Design

RCT, random order (crossover design), double-blind, placebo-controlled

Follow-up

up to ~60 minutes post-injection

Authors

MAMarkus AmannHeart Failure & Transplant GBGrégory M. BlainUtah Valley University LPLester T. ProctorUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

May refine models of cardiorespiratory control during exercise; confirms group III/IV afferents as key drivers in healthy humans.

Structured PICO

Does blockade of group III and IV muscle afferents with intrathecal fentanyl alter the ventilatory and cardiovascular responses to rhythmic exercise in healthy humans?

Population

7 moderately trained male cyclists (5 included in final exercise analysis), mean age 23.9 ± 3.6 years, body mass 74.0 ± 8.3 kg, maximal O2 consumption 66.0 ± 2.4 ml/kg/min.

Intervention

Lumbar intrathecal fentanyl (1 ml of 0.05 mg/ml) injected at the L3-L4 vertebral interspace prior to exercise to impair central projection of spinal opioid receptor-sensitive muscle afferents.

Comparator

Placebo (sham injection of 1 ml preservative-free normal saline into the ligaments at the L3-L4 vertebral interspace) prior to identical exercise.

Outcome

Ventilatory and cardiovascular responses to rhythmic leg and arm cycling exercise (including minute ventilation, VE/VCO2, end-tidal PCO2, heart rate, and mean arterial pressure).surrogate

Blockade of group III and IV muscle afferents with intrathecal fentanyl significantly attenuates the normal ventilatory and cardiovascular responses to rhythmic exercise in healthy humans.

Limitations

Potential limitations of surface EMG to reflect central motor drive due to filtering effects and amplitude cancellation
Unfavorable signal-to-noise ratio associated with exercise at low intensities for EMG measurement
Potential for cephalad migration of fentanyl within the CSF (which led to the exclusion of 2 subjects from the exercise analysis)

Cite This Study

Amann et al. (2010) studied this question.

synapsesocial.com/papers/6a107eb5d13714ec96fff01e https://doi.org/10.1152/japplphysiol.00462.2010

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Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider