Key result
Low-dose dobutamine echocardiography detected reversible dysfunction after thrombolytic therapy with 86% sensitivity and 90-93% specificity, outperforming peak CK (55% sensitivity, P<0.05).
Why the study?
Does multistage dobutamine echocardiography accurately detect reversible dysfunction in patients early after thrombolytic therapy for acute myocardial infarction?
Population
63 patients early after thrombolytic therapy for acute myocardial infarction
Comparison
Multistage dobutamine echocardiography performed… vs Signs of early reperfusion, non-Q-wave MI, and…
Design
Cohort
Follow-up
≥ 4 weeks
Authors
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Supports viability assessment with low-dose dobutamine echo early post-thrombolysis; hypothesis-generating and requires prospective validation before practice change.
Observational (n=63)
Does multistage dobutamine echocardiography accurately detect reversible dysfunction in patients early after thrombolytic therapy for acute myocardial infarction?
Absolute Event Rate: 86% vs 55%
p-value: p=<.05
Low-dose dobutamine echocardiography performed early after thrombolytic therapy for acute MI is a safe and highly sensitive and specific method for detecting reversible myocardial dysfunction.
Smart et al. (1993) conducted an observational in Acute myocardial infarction (n=63). Multistage dobutamine echocardiography vs. Non-Q-wave MI and peak creatine kinase was evaluated on Sensitivity for detecting reversible postischemic dysfunction (p=<.05). Low-dose dobutamine echocardiography detected reversible dysfunction after thrombolytic therapy with 86% sensitivity and 90-93% specificity, outperforming peak CK (55% sensitivity, P<0.05).
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