What is the clinical evidence from this study?

Population: Healthy sedentary (n=16). Intervention: Endurance exercise training vs. Baseline (before training). Primary outcome: Fractional shortening during highest dose of isoproterenol (p=<0.05).

January 1, 1992Journal of Applied Physiology

Exercise training improves left ventricular contractile response to beta-adrenergic agonist

Q: What are the key findings of this study?

Endurance exercise training for 12 weeks significantly improved left ventricular fractional shortening during maximal beta-adrenergic stimulation compared to baseline (56% vs 52%, P<0.05).

Q: What question did this study set out to answer?

To determine whether 12 weeks of endurance exercise training improves left ventricular contractile response to beta-adrenergic stimulation in young, sedentary individuals.

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Key result

Endurance exercise training for 12 weeks significantly improved left ventricular fractional shortening during maximal beta-adrenergic stimulation compared to baseline (56% vs 52%, P<0.05).

Why the study?

Does 12 weeks of endurance exercise training improve left ventricular contractile response to beta-adrenergic stimulation in young healthy sedentary subjects?

Key Points

To determine whether 12 weeks of endurance exercise training improves left ventricular contractile response to beta-adrenergic stimulation in young, sedentary individuals.
Assessed 16 young healthy sedentary adults (10 women, 6 men) before and after completing a 12-week endurance training regimen.
Prescribed training comprising interval running/cycling 3 days per week and continuous 40-minute running 3 days per week.
Measured left ventricular function using two-dimensional echocardiography under basal conditions and during graded isoproterenol infusion.
Endurance training increased maximal oxygen uptake from 41.0 ± 2 to 49.3 ± 2 ml·kg⁻¹·min⁻¹ (P < 0.01), with no change observed in basal fractional shortening (36 ± 1% vs. 36 ± 2%).
Fractional shortening during peak isoproterenol infusion increased from 52 ± 1% before training to 56 ± 1% after training (P < 0.05).
At comparable end-systolic wall stress levels, the isoproterenol-mediated increase in fractional shortening was greater after training (13 ± 1% vs. 17 ± 2%, P < 0.01), with greater end-systolic dimension reduction (-4.6 ± 0.1 mm vs. -7.0 ± 0.1 mm, P < 0.01).

Structured PICO

Does 12 weeks of endurance exercise training improve left ventricular contractile response to beta-adrenergic stimulation in young healthy sedentary subjects?

Population

16 young healthy sedentary subjects (10 women and 6 men)

Intervention

12 weeks of endurance exercise training (3 days/wk of interval training running and cycling, and 3 days/wk of continuous running for 40 min)

Comparator

Baseline state (before training)

Outcome

Left ventricular function in response to beta-adrenergic stimulation (isoproterenol infusion) evaluated by two-dimensional echocardiographysurrogate

Main Result

Absolute Event Rate: 56% vs 52%

p-value: p=<0.05

Endurance exercise training improves left ventricular contractile response to beta-adrenergic stimulation in young healthy subjects.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May enhance beta-adrenergic LV responsiveness in healthy youth; hypothesis-generating and should not yet change practice.

Cite This Study

Spina et al. (1992) studied Healthy sedentary (n=16). Endurance exercise training vs. Baseline (before training) was evaluated on Fractional shortening during highest dose of isoproterenol (p=<0.05). Endurance exercise training for 12 weeks significantly improved left ventricular fractional shortening during maximal beta-adrenergic stimulation compared to baseline (56% vs 52%, P<0.05).

synapsesocial.com/papers/6a1080bb5725bbd5cc611cd8 https://doi.org/10.1152/jappl.1992.72.1.307

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Exercise training improves left ventricular contractile response to beta-adrenergic agonist

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Exercise training improves left ventricular contractile response to beta-adrenergic agonist

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider