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October 11, 2024BioChemOpen Access

Appropriate Prescription of Non-Steroidal Anti-Inflammatory Drugs in Geriatric Patients—A Systematic Review

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Key result

Celecoxib and naproxen offer superior cardiovascular safety over diclofenac in elderly patients.

Why the study?

What are the cardiovascular, gastrointestinal, and renal safety profiles of different NSAIDs in elderly patients?

Population

Elderly patients (geriatric population)

Design

Systematic_review

Authors

CCCarolina CostaUniversidade do PortoDSDiana Gabriela SoaresUniversidade de São PauloABAna Flávia Sanches BorgesHospitais da Universidade de Coimbra

Discussion

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Implication

In elderly patients, celecoxib and naproxen are the preferred NSAIDs for cardiovascular safety, whereas diclofenac should be avoided.

Study Design

Type

Systematic Review

Structured PICO

What are the cardiovascular, gastrointestinal, and renal safety profiles of different NSAIDs in elderly patients?

P
Population
Systematic review of 39 studies evaluating the cardiovascular, gastrointestinal, and renal safety profiles of various NSAIDs in elderly patients.
I
Intervention
NSAIDs (ibuprofen, naproxen, acemetacin, diclofenac, celecoxib, and etoricoxib)
O
Outcome
Cardiovascular, gastrointestinal, and renal safety profilessafety

In elderly patients, celecoxib and naproxen are the preferred NSAIDs for cardiovascular safety, whereas diclofenac should be avoided.

Cite This Study

Costa et al. (2024) conducted a systematic review in Geriatric patients requiring NSAIDs. NSAIDs (ibuprofen, naproxen, acemetacin, diclofenac, celecoxib, etoricoxib) was evaluated on Cardiovascular, gastrointestinal, and renal safety profiles. A systematic review of 39 studies concluded that celecoxib or naproxen are preferred for cardiovascular safety in elderly patients, whereas diclofenac should be avoided.

synapsesocial.com/papers/6a108660d91177df95fcd0fdhttps://doi.org/10.3390/biochem4040015
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk of congestive heart failure with nonsteroidal antiinflammatory drugs and selective Cyclooxygenase 2 inhibitors: A class effect?2007 · 50 citations
  2. 2Long-term safety of naproxen and esomeprazole magnesium fixed-dose combination: phase III study in patients at risk for NSAID-associated gastric ulcers2011 · 25 citations
  3. 3Global population surpasses eight billion: Are we ready for the next billion?2023 · 41 citations
  4. 4Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review2023 · 234 citations