Why the study?
Defining epigenomic biomarkers of lifelong cardiovascular health exposure and understanding their roles in cardiovascular disease development may help develop preventive and therapeutic strategies.
Is cumulative cardiovascular health from young adulthood associated with midlife DNA methylation patterns and subsequent risk of coronary artery calcification and clinical CVD?
Population
1085 CARDIA study participants
Comparison
Cumulative cardiovascular health score over 20 years
Design
Epigenome-wide association study with replication in FHS
Follow-up
Over 20 years
Authors
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Methylation risk scores may aid midlife CVD prediction; leaves open causal mediation by CVH and prospective utility.
Is cumulative cardiovascular health from young adulthood associated with midlife DNA methylation patterns and subsequent risk of coronary artery calcification and clinical CVD?
Cumulative cardiovascular health from young adulthood is associated with midlife DNA methylation patterns, which in turn predict the risk of incident coronary artery calcification and clinical cardiovascular disease.
Zheng et al. (2022) studied this question.
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