What question did this study set out to answer?

To determine whether genetically predicted circulating lipid traits have a causal association with periodontitis risk using univariable and multivariable Mendelian randomization.

July 31, 2023Frontiers in EndocrinologyOpen Access

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

View Full Paper

Ask AI

Bookmark

Authors

GHGaofu HuSecond Affiliated Hospital of Zhejiang University CSChengjie SongShenzhen Technology University YYYuxuan YangBeijing Hospital of Traditional Chinese Medicine

Discussion

Member takes

Implication

Mendelian randomization study finds no causal link between circulating lipid traits and periodontitis, suggesting observed associations stem from confounding factors.

Key Points

To determine whether genetically predicted circulating lipid traits have a causal association with periodontitis risk using univariable and multivariable Mendelian randomization.
Extracted genetic instruments for five circulating lipid traits from two UK Biobank cohorts as exposure data.
Obtained periodontitis outcome data from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium.
Conducted univariable inverse variance weighted (IVW) analysis along with multivariable MR (MVMR-IVW and MVMR-robust), assessing pleiotropy and heterogeneity using Cochran Q, MR-PRESSO, and MR-Egger.
Univariable IVW MR suggested an association between genetically predicted apolipoprotein A1 and increased periodontitis risk (OR = 1.158, 95% CI = 1.007–1.331, P = 0.040), but statistical power was low.
Multivariable MR showed no significant causal relationship for apolipoprotein A1 (OR = 0.72, 95% CI = 0.36–1.41, P = 0.34), which was corroborated in the validation cohort (OR = 1.079, 95% CI = 0.903–1.290, P = 0.401).
Genetically predicted apolipoprotein B, HDL-C, LDL-C, and triglycerides showed no significant causal associations with periodontitis risk (all P > 0.05).

Cite This Study

Hu et al. (2023) studied this question.

synapsesocial.com/papers/6a108c8e01be78fe816107ec https://doi.org/10.3389/fendo.2023.1214232

View Full Paper

Ask AI

Bookmark

Implication

Mendelian randomization study finds no causal link between circulating lipid traits and periodontitis, suggesting observed associations stem from confounding factors.

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Discussion

Member takes

Implication

Key Points

Cite This Study

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider