Key result
Peak longitudinal atrial strain measured by cardiac MR feature tracking correlated strongly with the degree of fibrofatty myocardial replacement at histologic analysis (r = -0.75, P = 0.017).
Why the study?
Does LA strain quantification with cardiac MR correlate with the severity of LA fibrofatty myocardial remodeling in patients with mitral regurgitation?
Case-Control (n=26)
Does LA strain quantification with cardiac MR correlate with the severity of LA fibrofatty myocardial remodeling in patients with mitral regurgitation?
Effect estimate: r = -0.75
p-value: p=0.017
Left atrial strain, specifically peak longitudinal atrial strain measured by cardiac MR, is a noninvasive biomarker that strongly correlates with histologic fibrofatty replacement in patients with mitral regurgitation.
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May indicate LA fibrofatty remodeling severity via CMR strain in MR; leaves open validation for risk stratification.
Huber et al. (2017) conducted a case-control in Mitral regurgitation and left atrial fibrofatty remodeling (n=26). Cardiac MR feature tracking for left atrial strain quantification vs. Healthy control subjects was evaluated on Correlation between peak longitudinal atrial strain (PLAS) and degree of fibrofatty myocardial replacement at histologic analysis (r = -0.75, p=0.017). Peak longitudinal atrial strain measured by cardiac MR feature tracking correlated strongly with the degree of fibrofatty myocardial replacement at histologic analysis (r = -0.75, P = 0.017).
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