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April 15, 2021Frontiers in PharmacologyOpen Access

Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10

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Why the study?

Although AT2R activation increases the anti-inflammatory cytokine IL-10, its role in AT2R-mediated anti-inflammation and reno-protection in LPS-induced AKI was unknown.

Does AT2R stimulation by C21 prevent LPS-induced renal inflammation and injury via an IL-10-dependent mechanism in mice?

Population

Mice treated with LPS, C21, or LPS with C21 pre-treatment with or without neutralizing IL-10 antibody

Comparison

C21, LPS, and LPS plus C21 with vs without neutralizing IL-10 antibody

Design

Preclinical animal study

Follow-up

24 h

Authors

NFNaureen FatimaIntegral UniversitySPSanket PatelUniversity of HoustonTHTahir HussainUniversity of Houston

Discussion

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Member takes

Overview

IL-10 may mediate AT2R agonist renal protection in murine LPS-AKI; leaves open translation to human disease.

Structured PICO

Does AT2R stimulation by C21 prevent LPS-induced renal inflammation and injury via an IL-10-dependent mechanism in mice?

P
Population
121 male C57BL/6NHsd mice (8-10 weeks of age) subjected to lipopolysaccharide (LPS)-induced inflammation and acute kidney injury model.
I
Intervention
AT2R agonist C21 (0.3 mg/kg, intraperitoneally) administered 1 hour prior to LPS (5 mg/kg, intraperitoneally), with or without neutralizing IL-10 antibody.
C
Comparator
Normal saline, isotype control, LPS alone, C21 alone, or AT2R antagonist PD123319.
O
Outcome
Plasma and kidney levels of cytokines (IL-10, TNF-α, IL-6), renal function markers (BUN, urinary creatinine), and renal injury markers (KIM-1, NGAL) at 1, 2, 6, and 24 hours.surrogate

AT2R stimulation by C21 protects against LPS-induced acute kidney injury and renal inflammation through an IL-10-dependent mechanism in the kidney.

Cite This Study

Fatima et al. (2021) studied this question.

synapsesocial.com/papers/6a109b28d478ddac0ffd43f4https://doi.org/10.3389/fphar.2021.600163
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Also Consider

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