A systematic review of 12 studies and 853 participants found that adults with obstructive sleep apnea demonstrate diminished vagal tone and higher sympathetic responsiveness compared to controls.
Systematic Review (n=853)
Does obstructive sleep apnea alter heart rate variability in adults compared to controls?
Adults with obstructive sleep apnea exhibit altered heart rate variability characterized by diminished vagal tone and increased sympathetic responsiveness, indicating autonomic dysregulation.
Obstructive Sleep Apnea is a common respiratory disorder characterized by recurrent nocturnal episodes of normal breathing interruption due to upper airway total or partial collapse. Obstructive sleep apnea and cardiovascular diseases has similar risk factors, but the first is also a predisposing factor for cardiovascular pathologies independently of individuals demographic characteristics or risk markers. Heart rate variability is a non-invasive method to evaluate the regulation of autonomic nervous system and its a promising marker for health and disease, such as cardiovascular and respiratory diseases. The aim was to review whether heart rate variability is altered in patients with obstructive sleep apnea. We searched in five databases, including BIREME, Cochrane, Scholar Google, MEDLINE/PubMed and Periodics CAPES, and reference lists were also searched. Only cross-sectional studies comparing the heart rate variability of obstructive sleep patients with controls were included. Two authors independently extracted data and assessed trial quality. Twelve studies (513 participants with obstructive sleep apnea and 340 controls) met the inclusion criteria. This review evidence that adults with obstructive sleep apnea may demonstrate diminished vagal tone and higher sympathetic responsiveness.
Sequeira et al. (Sun,) conducted a systematic review in Obstructive sleep apnea (n=853). Obstructive sleep apnea vs. Controls was evaluated on Heart rate variability. A systematic review of 12 studies and 853 participants found that adults with obstructive sleep apnea demonstrate diminished vagal tone and higher sympathetic responsiveness compared to controls.