The cell’s autonomous response window for advanced healing

While homeostasis has been defined to date and a common understanding exists of its context and how it responds to stress, there is still a need for a better understanding of how homeostasis is regained and for the boundaries defining the physiological and pathological responses of tissue/microenvironment under stress. A modern adaptability view should improve our understanding of how the prior status (host health) or resilience is reinstated. The living entity, regarded as a superorganism that coexists with a microbiota and participates in the process, not neglecting the role of constitutive innate immunity in providing formidable defenses and access to superior healing with regenerative probabilities ‒if properly elicited, should corroborate its remote origins and early description dating back to 1900, by Adami (cited below). The method is an integrative collation of the basic science underpinning the new principle of tissue/microenvironmental control, that exploits the opportunities within the cell autonomous response as preference to an adaptive outcome. Both in-depth Literature search and the historical proprietary preclinical and clinical research that led to its establishment are taken into account and explain how over 25 years the improved outcomes of healing were discovered. Finally, how efficacy and safety of the methodology validated prior statistical expectations, allowing its characterization as a standard method for wound healing that gained sanitary registration and translated into a standard intervention for wound healing. This new knowledge has translated into forms of inter-polyelectrolyte, hydro, and liposoluble forms of interventions with superior safety, efficacy, much lessened pain awareness, abatement of inflammation, absence of infection, and tissue regeneration when used immediately after injury, and unusual practicality at a very reasonable cost. Furthermore, the evidence compiled in humans from the standard practice of this validated “as-safe” new methodology is concordant with the existence of healing within innate immunity. The practicality and efficacy of microenvironment control by inter-polyelectrolyte layers embodying an autacoid, is more inclusive to convey the necessary cues to the interactome (tissue/microenvironment) with the capability of interacting with the constitutive innate immunity frame, rescuing deviations of homeostasis back into the correct path towards thorough resolution, adaptation, and reinstatement of host health by regeneration. Not only a contrasting concept to the universally accepted healing ending in fibrosis, but it is also exemplary of what it takes to intervene disease. What is already known about the cell’s autonomous response, dating back to 1900 and foreseen by Adami1, is presented in the Introduction, Preamble, and Literature Overview.The study situates the response where it belongs clinically for the first time, and describes its nature, separating it from inflammation, and clarifies the transition towards adaptive immunity as maladaptive, given the stark contrast in results. It then unveils a trove of potent defenses, as healing with regeneration, breaks the news regarding translation to the clinic of findings and benefits of the methodology of tissue/microenvironment control made available to end users affordably and with unprecedented safety. The range of application of the methodology spans from trivial situations to solving critical cases. Mastering the inflammatory common pathobiology of intermediate phenotypes implies embracing the morbidity of many non-communicable diseases and reducing their mortality. Emergence of the methodology paired with a spontaneous version of co-production may exemplify how future research might be simplified if the focus is steered towards systems medicine and away from single-nodal target approaches. How this paper will affect practice is obvious if the methodology is applied within the constitutive window of innate immunity (immediately) since paligenosis probably will result, or else, scarring and pain will decrease, and infection will be absent. The conceptualization of how it will affect policy is complex and requires special consideration. This can be found externally, with a link referenced in the section below of Social Value and Impact.