Key result
Elevated NT-proBNP and higher NYHA class weakly predict poor sleep quality in chronic heart failure.
Why the study?
The study was conducted to assess sleep quality and its influencing factors in patients with chronic heart failure.
Observational (n=112)
Impaired sleep is prevalent in chronic heart failure patients and is independently associated with disease severity markers including NT-proBNP and NYHA class.
NYHA class and NT-proBNP may flag HF patients with poor sleep; hypothesis-generating and should not yet change practice.
Objective To assess sleep quality and its influencing factors in patients with chronic heart failure (CHF). Methods A study of 112 CHF patients was conducted using the Pittsburgh Sleep Quality Index (PSQI). Clinical and socio‐demographic data were collected. Relationships were analyzed via multiple linear regression (with LASSO for variable selection), and feature importance was evaluated with a random forest model, validated by training‐test splitting and SHAP analysis. Results PSQI scores were significantly elevated in CHF patients. Multiple regression identified NYHA class and NT‐proBNP as independent predictors of poor sleep, while longer heart failure duration was inversely associated with PSQI in the adjusted model—a finding that warrants further investigation. LASSO selected these three variables. Random forest indicated NT‐proBNP had the highest feature importance, confirmed by SHAP, though the model's predictive performance was limited ( R 2 = 0.049). Conclusion Impaired sleep is prevalent in CHF and is significantly associated with disease severity markers NT‐proBNP and NYHA class, highlighting sleep management as a potential component of comprehensive care.
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Chu et al. (2026) conducted an observational in chronic heart failure (n=112). Elevated NT-proBNP and higher NYHA class were independent predictors of poor sleep quality in patients with chronic heart failure, though the predictive model's performance was limited (R2 = 0.049).
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