What question did this study set out to answer?

To design and validate a brief structured telephone interview for verifying the stroke-free phenotype in candidates for genetic linkage studies.

May 1, 2000StrokeOpen Access

Verifying the Stroke-Free Phenotype by Structured Telephone Interview

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Authors

JMJames F. MeschiaRutgers, The State University of New Jersey TBThomas G. BrottVascular Medicine FCFelix E. ChukwudelunzuMayo Clinic Health System

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Implication

Diagnostic study demonstrates perfect sensitivity and negative predictive value for a telephone interview in older outpatients, suggesting its utility for genetic linkage studies.

Key Points

To design and validate a brief structured telephone interview for verifying the stroke-free phenotype in candidates for genetic linkage studies.
A blinded coordinator conducted an 8-item structured telephone interview assessing sudden neurological deficits (strength, sensation, vision, language) in 70 outpatients aged >60 years.
Interview outcomes were benchmarked against systematic medical record reviews to verify stroke-free status.
Medical record review detected ischemic stroke or transient ischemic attack (TIA) in 5 of 70 patients (7%).
Reporting one or more positive questionnaire items was significantly associated with a confirmed diagnosis of stroke (P<0.001), TIA (P<0.001), or either event (P<0.001).
The telephone interview achieved a sensitivity of 1.0 (95% CI 0.48 to 1.0), specificity of 0.86 (95% CI 0.75 to 0.93), positive predictive value of 0.36 (95% CI 0.13 to 0.65), and negative predictive value of 1.0 (95% CI 0.94 to 1.0).

Cite This Study

Meschia et al. (2000) studied this question.

synapsesocial.com/papers/6a10a72e5725bbd5cc615503 https://doi.org/10.1161/01.str.31.5.1076

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Implication

Diagnostic study demonstrates perfect sensitivity and negative predictive value for a telephone interview in older outpatients, suggesting its utility for genetic linkage studies.

Verifying the Stroke-Free Phenotype by Structured Telephone Interview

Discussion

Member takes

Implication

Key Points

Cite This Study

Verifying the Stroke-Free Phenotype by Structured Telephone Interview

Discussion

Member takes

Implication

Key Points

Cite This Study

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