Key result
The 2003 AHA definition using troponins identified 83% more MIs than the WHO MONICA definition, and these additional patients had a higher 1-year risk of cardiovascular death (HR 1.6; 95% CI 1.1-2.2).
Why the study?
Does the 2003 AHA definition of MI using troponins identify more patients at high risk of cardiovascular death compared to the WHO MONICA definition?
Population
6,104 hospitalized patients with suspected acute coronary syndromes with data on either troponin T or…
Comparison
2003 American Heart Association Scientific… vs WHO MONICA definition of myocardial infarction…
Design
Cohort
Follow-up
1 year
Authors
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Supports troponin-based MI definitions to capture higher-risk ACS patients; leaves open effects on management and trial endpoints.
Observational (n=6,104)
Does the 2003 AHA definition of MI using troponins identify more patients at high risk of cardiovascular death compared to the WHO MONICA definition?
Effect estimate: HR 1.6 (95% CI 1.1-2.2)
The 2003 MI definition using troponins identifies a significantly larger group of patients with suspected ACS who are at high risk for cardiovascular death compared to older enzyme-based definitions.
Salomaa et al. (2005) conducted an observational in suspected acute coronary syndromes (n=6,104). 2003 AHA definition of MI vs. WHO MONICA definition was evaluated on cardiovascular death within 1 year (HR 1.6, 95% CI 1.1-2.2). The 2003 AHA definition using troponins identified 83% more MIs than the WHO MONICA definition, and these additional patients had a higher 1-year risk of cardiovascular death (HR 1.6; 95% CI 1.1-2.2).
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