The Medication-Related Burden Quality of Life (MRB-QoL) tool: A confirmatory factor analysis of the Arabic version

Background: The Medication-Related Burden Quality of Life (MRB-QoL) Arabic version is a 31-item valid and reliable measure of medication burden on functioning and well-being. Objective: To examine the factor structure of the MRB-QoL Arabic in a sample of adults living with long-term conditions (LTC). Methods: /df < 5, and CFI, IFI, and TLI ≥ 0.90 were considered indicators of good model fit. PNFI and PCFI >0.5 were also considered as indicators of good fit. CR ≥ 0.7, AVE ≥ 0.5, and AVE greater than squared factors correlation were considered as evidence indicating reliability, convergent validity, and discriminant validity, respectively. Results: The first-order model showed an excellent fit (χ2/df = 3.262, RMSEA = 0.08, SRMR = 0.05, CFI = 0.913, TLI = 0.914, IFI = 0.914, PNFI = 0.810, PCFI = 0.841) as did the second-order model (χ2/df = 2.845, RMSEA = 0.073, SRMR = 0.072, CFI = 0.934, TLI = 0.923, IFI = 0.915, PNFI = 0.820, PCFI = 0.851). All domains of the MRB-QoL met the convergent/discriminant validity and reliability criteria. Conclusions: The study supports the factor structure from previous research and confirms the MRB-QoL Arabic as a valid and reliable measure. This tool can be used to assess medicines burden from patient perspectives and facilitate person-centred care in medicines optimisation services across Arabic-speaking countries.