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The study aims to determine the role of interleukin 2 receptor (IL 2R) expression in the proliferation of activated HNK-1+ granular lymphocytes.

Interleukin 2 receptor expression by activated HNK-1+ granular lymphocytes: a requirement for their proliferation.

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The study aims to determine the role of interleukin 2 receptor (IL 2R) expression in the proliferation of activated HNK-1+ granular lymphocytes.
Blood mononuclear cells stimulated with phytohemagglutinin, concanavalin A, or pokeweed mitogen for up to 6 days.
Monitored expression of IL 2R using anti-Tac monoclonal antibody after various stimulations.
Established long-term cultures of HNK-1+ cells with continuous IL 2 presence to assess proliferation.
One-fourth of HNK-1+ cells expressed IL 2R within 18 hours post-stimulation.
Proliferation of HNK-1+ cells was completely inhibited by the addition of anti-Tac antibody.
Growth cycle entry for HNK-1+ granular lymphocytes requires dual signals: ligand interaction and IL 2 receptor engagement.

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Randomized trial examines interleukin 2 receptor expression for proliferation in HNK-1+ cells, indicating their activation requirements.

Abo et al. (1983) studied this question.

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