Adiposity and Cardiac Defects: Pathophysiology and Etiology

Q: What is the clinical evidence from this study?

Study design: Review. Population: Obesity and Cardiovascular Disease. Intervention: Obesity vs. Normal weight.

Q: What does this research mean for the field?

Obesity and excess weight increase the risk of cardiovascular disease through both direct myocardial effects, such as structural adaptations and cardiomyopathy, and associated metabolic conditions. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Gaurav Koparkar; Dalia Biswas

doi:10.7759/cureus.34026

January 21, 2023CureusOpen Access

Adiposity and Cardiac Defects: Pathophysiology and Etiology

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Key Points

To delineate the pathophysiology and etiology linking excess adiposity and abdominal obesity to structural and functional cardiovascular defects.
Narrative synthesis of literature evaluating the direct and indirect mechanisms of obesity-induced cardiovascular disease and hemodynamic adaptations.
Adipose tissue expansion increases metabolic demands, elevating stroke volume and cardiac output while inducing structural remodeling termed adipositas cordis.
Abdominal adiposity independently drives cardiovascular disease risk alongside comorbid factors including dyslipidemia, hypertension, and type 2 diabetes.
Direct structural adaptations to excess fat accumulation predispose individuals to coronary artery disease, cardiomyopathy, cardiac arrest, and sudden cardiac death.

PICO

P

Population

Obesity and Cardiovascular Disease

I

Intervention / Comparator

Obesity vs Normal weight

Limitations

Clinical evaluation of obese individuals for heart failure is challenging due to morphological constraints, making physical examinations difficult.

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Implication

This review highlights the direct and indirect pathophysiological mechanisms by which obesity leads to structural heart changes and cardiovascular disease.

Abstract

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Cite This Study

Koparkar et al. (2023) conducted a review in Obesity and Cardiovascular Disease. Obesity vs. Normal weight was evaluated.

synapsesocial.com/papers/6a10b927acd1dbe064644e88 https://doi.org/10.7759/cureus.34026

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Adiposity and Cardiac Defects: Pathophysiology and Etiology

Figures

Key Points

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Adiposity and Cardiac Defects: Pathophysiology and Etiology

Figures

Key Points

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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