CMR Characteristics, gene variants and long-term outcome in patients with left ventricular non-compaction cardiomyopathy

Figures

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  Fig. 1. CMR characteristics and genetics in LVNC. a The orange line identifies the thickness of the compacted layer, and the blue line identifies the thickness of the trabeculated layer. Standard epicardial contours (green line) and endocardial contours (red line) for measurement of the compacted myocardial mass and the papillary muscles (yellow line, pink line) were included from the measurements. Endocardial contours (red line) at the border of the non-compacted myocardium for measurement of the ‘global myocardial mass.’ The non-compacted mass (orange region) was subsequently calculated by subtracting compacted mass and papillary muscle mass from global LV myocardial mass. b Spectrum of pathogenic variants in this cohort

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  Fig. 2. Correlations among carriers of multiple variants, G+ group and G− group in LVEF (a), LVCI (b) and LGE (c). p values for independent t test or Mann–Whitney U-test between parameters from carriers of multiple variants and G− group. G+ genotype positive, G- genotype negative, LVEF left ventricular ejection fraction, LVCI left ventricular cardiac index, LGE late gadolinium enhancement

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  Fig. 3. Correlations among carriers of multiple variants, G+ group and G− group in left atrial volume (a), left atrial emptying fraction (b), and left atrial longitudinal strain (c). p values for independent t test or Mann–Whitney U-test between parameters from carriers of multiple variants and G− group. G+ genotype positive, G− genotype negative, LAVmax maximal left atrial volume, LAVpre-a left atrial volume before LA contraction, LAVmin minimal left atrial volume, LAEF left atrial emptying fraction, εs total strain, εe passive strain, εa active strain

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  Fig. 4. Receiver operating characteristic curve analysis for discriminating patients with positive genotype (a) and multiple genetic mutations (b). AUC area under the curve, LAVmax maximal left atrial volume, LAVpre-a left atrial volume before LA contraction, LAVmin minimal left atrial volume

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  Fig. 5. Kaplan–Meier survival curves for survival free of the primary endpoint according to positive genotype (a) and multiple genetic mutations (b). G+ genotype positive, G− genotype negative