Key result
The combination of depression and sleep apnea in patients with recent AMI was associated with a 3.9- and 6.9-times higher prevalence of death/recurrent AMI and death alone than predicted (p<.001).
Why the study?
Does the combination of depression and sleep apnea increase the risk of death or recurrent AMI in patients with a recent acute myocardial infarction?
Population
716 patients with a recent acute myocardial infarction, including 337 depressed and 379 nondepressed…
Comparison
Presence of both depression and sleep apnea vs Presence of depression alone, sleep apnea alone…
Design
Cohort
Follow-up
median 25 months
Authors
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May identify high-risk post-AMI patients for screening; leaves open whether treating both conditions improves outcomes.
Cohort (n=716)
Does the combination of depression and sleep apnea increase the risk of death or recurrent AMI in patients with a recent acute myocardial infarction?
p-value: p=<.001
The combination of depression and sleep apnea synergistically increases the risk of death and recurrent AMI in patients recovering from a recent myocardial infarction.
Hayano et al. (2012) conducted a cohort in recent acute myocardial infarction (AMI) (n=716). Depression and sleep apnea vs. Depression alone, sleep apnea alone, or neither was evaluated on Death or recurrent AMI (p=<.001). The combination of depression and sleep apnea in patients with recent AMI was associated with a 3.9- and 6.9-times higher prevalence of death/recurrent AMI and death alone than predicted (p<.001).
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