What question did this study set out to answer?

To assess how glucose-modified proteins stimulate cytokine release by macrophages and to define their potential function in physiological tissue turnover.

June 10, 1988Science

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

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Authors

HVHelen VlassaraStowers Institute for Medical Research MBMichael BrownleeAlbert Einstein College of Medicine KMKirk R. ManogueFeinstein Institute for Medical Research

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Implication

Mechanistic study reveals glucose-modified proteins trigger cytokine secretion in macrophages, suggesting a physiological role in extracellular matrix turnover.

Key Points

To assess how glucose-modified proteins stimulate cytokine release by macrophages and to define their potential function in physiological tissue turnover.
Examined macrophage receptor-mediated recognition, uptake, and catabolism of advanced glycosylation end products (AGEs).
Measured the secretion of cachectin (tumor necrosis factor) and interleukin-1 by macrophages following exposure to AGE proteins.
Macrophage receptors mediate the targeted uptake and degradation of AGE-modified proteins.
Receptor-mediated clearance of AGE proteins induces the synthesis and secretion of cachectin and interleukin-1, identifying a pathway for removing and renewing senescent extracellular matrix components.

Cite This Study

Vlassara et al. (1988) studied this question.

synapsesocial.com/papers/6a10bc0cf85e2d3f759f5786 https://doi.org/10.1126/science.3259727

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Implication

Mechanistic study reveals glucose-modified proteins trigger cytokine secretion in macrophages, suggesting a physiological role in extracellular matrix turnover.

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

Discussion

Member takes

Implication

Key Points

Cite This Study

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

Discussion

Member takes

Implication

Key Points

Cite This Study

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