Key result
SNRI and tricyclic antidepressant use during pregnancy were associated with a higher risk of preeclampsia compared to no exposure (RR 1.52 and 1.62, respectively) and compared to SSRIs.
Why the study?
Do specific antidepressants increase the risk of preeclampsia in pregnant women with depression?
Population
100,942 pregnant women with depression from 2000 to 2007 US nationwide Medicaid Analytic eXtract (MAX) data.
Comparison
Selective serotonin reuptake inhibitor… vs Women with depression and no antidepressant…
Design
Cohort
Follow-up
Through delivery
Authors
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SNRI/TCA use may raise preeclampsia risk in pregnancy; leaves open causality and optimal choice pending prospective data.
Cohort (n=100,942)
Yes
Do specific antidepressants increase the risk of preeclampsia in pregnant women with depression?
Effect estimate: RR 1.52 (95% CI 1.26-1.83)
In pregnant women with depression, the use of SNRIs and tricyclic antidepressants during pregnancy is associated with an increased risk of preeclampsia, whereas SSRI use is not.
Palmsten et al. (2013) conducted a cohort in Pregnant women with depression (n=100,942). SNRI and tricyclic antidepressants vs. No antidepressant exposure or SSRI monotherapy was evaluated on Preeclampsia (RR 1.52, 95% CI 1.26-1.83). SNRI and tricyclic antidepressant use during pregnancy were associated with a higher risk of preeclampsia compared to no exposure (RR 1.52 and 1.62, respectively) and compared to SSRIs.
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