Systematic review finds no reduction in mortality or primary outcomes with calcium antagonists in acute ischemic stroke, indicating a lack of clinical benefit.
Cochrane Database of Systematic Reviews and lifarizine. More than half of these trials followed participants for at least three months. Calcium antagonists showed no e ects on the primary outcome (risk ratio (RR) 1.05; 95% confidence interval (CI) 0.98 to 1.13; 22 trials; 22 studies; 6684 participants; moderate-quality evidence) or on death at the end of follow-up (RR 1.07, 95% CI 0.98 to 1.17; 31 trials; 7483 participants; moderate-quality evidence). Thirteen trials reported adverse events, finding no significant di erences between groups. Most trials did not report the allocation process or how they managed missing data, so we considered these at high risk of selection and attrition bias. Most trials reported double-blind methods but did not state who was blinded, and none of the trial protocols were available.
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