December 15, 2011The Journal of Clinical Endocrinology & MetabolismOpen Access

Tight Glycemic Control May Increase Regenerative Potential of Myocardium during Acute Infarction

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Why the study?

Does intensive glycemic control improve the regenerative potential of the myocardium in patients with acute myocardial infarction undergoing coronary bypass surgery?

Population

75 patients with their first acute myocardial infarction undergoing coronary bypass surgery

Comparison

Intensive glycemic control using insulin… vs Conventional glycemic control or…

Design

RCT, randomized

Follow-up

almost 3 days

Authors

RMRaffaele MarfellaPreventive Cardiology FSFerdinando Carlo SassoHeart Failure & Transplant FCFederico CacciapuotiUniversity of Campania "Luigi Vanvitelli"

Discussion

Member takes

Implication

Supports intensive glycemic control in AMI-CABG to enhance myocardial regeneration; extends RCT evidence to myocyte precursor cell dynamics.

Structured PICO

Does intensive glycemic control improve the regenerative potential of the myocardium in patients with acute myocardial infarction undergoing coronary bypass surgery?

Population

75 patients with their first acute myocardial infarction undergoing coronary bypass surgery (25 normoglycemic controls, 50 hyperglycemic patients randomized)

Intervention

Intensive glycemic control (IGC; glucose goal 80-140 mg/dl) using insulin infusion followed by subcutaneous insulin treatment for almost 3 days before surgery

Comparator

Conventional glycemic control (CGC; glucose goal 180-200 mg/dl) or glucose-insulin-potassium (GIK; glucose goal 180-200 mg/dl)

Outcome

Myocyte precursor cells (MPC), oxidation of MPC DNA, senescent MPC, and cycling cardiomyocytes in biopsy specimens taken from the peri-infarcted area during surgerysurrogate

Tight glycemic control in patients with acute myocardial infarction undergoing CABG may increase the regenerative potential of the ischemic myocardium by reducing senescent myocyte precursor cells.

Cite This Study

Marfella et al. (2011) studied this question.

synapsesocial.com/papers/6a10c1218102eb4b66ee51ee https://doi.org/10.1210/jc.2011-2037

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Implication

Supports intensive glycemic control in AMI-CABG to enhance myocardial regeneration; extends RCT evidence to myocyte precursor cell dynamics.

Tight Glycemic Control May Increase Regenerative Potential of Myocardium during Acute Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tight Glycemic Control May Increase Regenerative Potential of Myocardium during Acute Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider