The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.1987 · 774 citations
2. 2Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin1993 · 68 citations
3. 3Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.1994 · 541 citations
4. 4Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction1996 · 685 citations
5. 5AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation1995 · 163 citations