Key result
T2DM is linked to ~120% higher malondialdehyde levels and lower ferric reducing ability of plasma.
Why the study?
Type 2 diabetes mellitus is increasing, and increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity.
Are oxidative stress (MDA) and antioxidant capacity (FRAP) altered in patients with type 2 diabetes mellitus compared to controls?
Case-Control (n=126)
No
Are oxidative stress (MDA) and antioxidant capacity (FRAP) altered in patients with type 2 diabetes mellitus compared to controls?
Absolute Event Rate: 4.84% vs 2.2%
p-value: p=0.0001
Patients with type 2 diabetes mellitus demonstrate increased oxidative stress and reduced antioxidant capacity.
No takes yet. Share an insight, caveat, or question.
Oxidative stress markers associate with T2DM; hypothesis-generating and should not yet change practice.
Kidwai et al. (2022) conducted a case-control in Type 2 diabetes mellitus (n=126). Type 2 diabetes mellitus (Exposure) vs. Healthy controls was evaluated on Malondialdehyde (MDA) level (p=0.0001). Type 2 diabetes mellitus patients had significantly higher malondialdehyde levels (4.84 vs 2.20) and lower ferric reducing ability of plasma compared to healthy controls.
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