Key result
Exercise improves VO2peak, resting heart rate, and diastolic blood pressure vs control in cancer patients.
Why the study?
The review aimed to evaluate the effects of exercise-based interventions on cancer therapy-related cardiovascular toxicity in individuals with cancer.
Do exercise-based interventions prevent or treat cancer therapy-related cardiovascular toxicity in individuals with cancer?
Meta-Analysis (n=2,484)
Do exercise-based interventions prevent or treat cancer therapy-related cardiovascular toxicity in individuals with cancer?
Exercise-based interventions demonstrate a potential role in preventing and treating cancer therapy-related cardiovascular toxicity, specifically by lowering resting diastolic blood pressure and heart rate.
Supports exercise integration into cardio-oncology care; extends evidence for mitigating therapy-related cardiovascular toxicity.
PURPOSE: This review aimed to evaluate the effects of exercise-based interventions on cancer therapy-related cardiovascular toxicity (CTR-CVT) in individuals with cancer. METHODS: Four databases (MEDLINE, Embase, Web of Science, and CENTRAL) were searched to identify eligible studies. Randomized controlled trials examining the effects of exercise-based interventions on CTR-CVT in cancer patients published in English were included. The risk of bias of included studies was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials. The meta-analysis was performed using statistical software R. The PRISMA statement was followed. RESULTS: (mean difference [MD]: 1.62, 95% confidence interval [CI]: 0.94 to 2.30), resting diastolic blood pressure (MD: -4.43, 95% CI: -8.72 to -0.13), and resting heart rate (MD=-3.74, 95% CI: -6.59, -0.89) among individuals with cancer. Evidence on other study outcomes remains unclear. CONCLUSION: The findings of this review demonstrate the potential role of exercises in preventing and treating CTR-CVT. Further research is warranted to strengthen the current evidence and fill the gaps identified in this review. REGISTRATION: The review protocol was registered in PROSPERO (ID: CRD42022380550).
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Wang et al. (2025) conducted a meta-analysis in Cancer therapy-related cardiovascular toxicity (n=2,484). Exercise-based interventions vs. Control (placebo, usual care, wait-list, or attention control) was evaluated on VO2peak (MD 1.62, 95% CI 0.94 to 2.30, p=<0.001). Exercise-based interventions significantly improved VO2peak (MD 1.62), resting diastolic blood pressure (MD -4.43), and resting heart rate (MD -3.74) compared to control in individuals with cancer.
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