A 12-week protocol of resistance or aerobic exercise training in breast cancer survivors improved specific cardiometabolic parameters, with no significant differences in long-term outcomes at 34 months.
Cohort (n=57)
Does a 12-week aerobic or resistance exercise training protocol improve cardiometabolic profile, quality of life, and long-term outcomes in breast cancer survivors not treated with chemotherapy?
Aerobic and resistance exercise training induce specific positive cardiometabolic adaptations in breast cancer survivors, supporting their inclusion in cardio-oncology rehabilitation programs.
BACKGROUND: Breast cancer (BC) and cardiovascular (CV) disease share many risk factors associated with worse outcomes, in terms of cancer relapse, CV events, and quality of life (QoL), that could be counteracted by physical exercise (PE). We aimed to assess the impact of a 12-week differential PE protocol on cardiometabolic profile, QoL, CV- and BC-related long-term outcomes, and physical activity (PA) in a cohort of BC survivors (BCS) not treated with chemotherapy. METHODS: 57 BCS participated in a 12-week PE protocol aerobic exercise training (AET) or resistance exercise training (RET). Anthropometric and CV evaluation, health-related (HR)-QoL, daily PA, cortisol, and dehydroepiandrosterone sulfate (DHEA-S) levels were assessed before (T0) and after (T1) PE. We assessed BC and CV outcomes, HR-QoL, CV-QoL, and PA at the follow-up. RESULTS: RET improved waist circumference, DHEA-S, cortisol/DHEA-S, systolic and mean blood pressure, and ventricular/arterial coupling; AET ameliorated sagittal abdomen diameter and pulse wave velocity. Regarding HR-QoL, physical function improved only in AET group. At a mean 34 ± 3.6-month follow-up, we documented no significant differences in CV-QoL, HR-QoL, and PA or CV and BC outcomes. CONCLUSIONS: AET and RET determine specific, positive adaptations on many parameters strongly related to CV risk, CV and BC outcomes, and QoL, and should be included in any cardio-oncology rehabilitation program.
Bucciarelli et al. (Thu,) conducted a cohort in Breast cancer (n=57). Aerobic exercise training (AET) or resistance exercise training (RET) vs. AET vs RET was evaluated on Cardiometabolic profile, QoL, CV- and BC-related long-term outcomes, and physical activity. A 12-week protocol of resistance or aerobic exercise training in breast cancer survivors improved specific cardiometabolic parameters, with no significant differences in long-term outcomes at 34 months.