What question did this study set out to answer?

To assess whether the tyrosine kinase inhibitor CGP 57148 can suppress cell growth driven by diverse activated ABL variants and the TEL-PDGFR fusion oncoprotein.

December 15, 1997Blood

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

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To assess whether the tyrosine kinase inhibitor CGP 57148 can suppress cell growth driven by diverse activated ABL variants and the TEL-PDGFR fusion oncoprotein.
Assayed ABL tyrosine phosphorylation and cellular growth inhibition across cell lines expressing p185BCR-ABL, TEL-ABL, and TEL-PDGFR in the absence of growth factors.
Tested compound sensitivity in a patient-derived cell line harboring Philadelphia chromosome-positive, p185BCR-ABL-driven acute lymphocytic leukemia.
CGP 57148 blocked ABL kinase activity and growth in p185BCR-ABL- and TEL-ABL-expressing cells at concentrations comparable to those effective against p210BCR-ABL.
Suppressed proliferation in a patient-derived Philadelphia chromosome-positive acute lymphocytic leukemia cell line expressing p185BCR-ABL.
Demonstrated marked growth inhibition in cells driven by the TEL-PDGFR fusion kinase.

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Implication

In vitro study demonstrates CGP 57148 inhibits growth in leukemic cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusions, suggesting therapeutic potential across diverse kinase-driven leukemias.

Cite This Study

Carroll et al. (1997) studied this question.

synapsesocial.com/papers/6a10c7c58102eb4b66ee628e https://doi.org/10.1182/blood.v90.12.4947.4947_4947_4952

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Implication

In vitro study demonstrates CGP 57148 inhibits growth in leukemic cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusions, suggesting therapeutic potential across diverse kinase-driven leukemias.

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

Key Points

Discussion

Implication

Cite This Study

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider