Why the study?
Systemic inflammation affects diabetes and cardiovascular prognosis, but the prognostic significance of the system inflammation response index in patients with both AF and T2DM was unknown.
Does an elevated System Inflammation Response Index (SIRI) predict mortality in patients with atrial fibrillation and type 2 diabetes mellitus?
Population
2054 AF and T2DM patients in the MIMIC-IV repository
Comparison
Three groups based on SIRI index tertiles
Design
Retrospective cohort study
Follow-up
1 year
Key result
Patients with atrial fibrillation and type 2 diabetes in the highest SIRI tertile had an 86% increased risk of in-hospital all-cause mortality (HR 1.863) compared to the lowest tertile.
Authors
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May aid in-hospital risk stratification in AF with diabetes; leaves open whether SIRI improves existing models.
Observational (n=2,054)
No
Does an elevated System Inflammation Response Index (SIRI) predict mortality in patients with atrial fibrillation and type 2 diabetes mellitus?
Effect estimate: HR 1.863 (95% CI 1.189-2.918)
p-value: p=0.007
Elevated System Inflammation Response Index (SIRI) is an independent predictor of in-hospital and 1-year mortality in patients with concurrent atrial fibrillation and type 2 diabetes mellitus.
Chen et al. (2025) conducted an observational in Atrial fibrillation and type 2 diabetes mellitus (n=2,054). Highest tertile of System Inflammation Response Index (>5.701) vs. Lowest tertile of System Inflammation Response Index (<2.591) was evaluated on All-cause mortality during hospitalization (HR 1.863, 95% CI 1.189-2.918, p=0.007). Patients with atrial fibrillation and type 2 diabetes in the highest SIRI tertile had an 86% increased risk of in-hospital all-cause mortality (HR 1.863) compared to the lowest tertile.
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