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July 19, 2026MedicineOpen Access

Association of AISI and SIRI levels with mortality risk in patients with type 2 diabetes: A retrospective cohort study

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Authors

SWS W WangMLM M LiuSCShaotao Chen

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Overview

Retrospective cohort study assesses AISI and SIRI levels' impact on mortality risk in type 2 diabetes, suggesting their use as prognostic markers.

Key Points

  • This study aims to evaluate how AISI and SIRI levels relate to mortality risks in patients with type 2 diabetes.
  • Combined analysis of Global Burden of Disease data from 1990 to 2021 and NHANES data from 1999 to 2018.
  • Linked National Death Index mortality files to assess outcomes.
  • Evaluated the association between quartiles of AISI and SIRI with CVD and all-cause mortality.
  • AISI quartile 4 (Q4) shows HR=1.46 for CVD and HR=1.71 for all-cause mortality compared to Q1.
  • SIRI quartile 4 (Q4) indicates HR=1.98 for CVD and HR=2.13 for all-cause mortality compared to Q1.
  • Higher levels of AISI and SIRI correlate with increased mortality risks.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a5c6999118b92953e3edeechttps://doi.org/10.1097/md.0000000000049713
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