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September 10, 2025Medical Research

Prognostic Effect of the Aggregate Index of Systemic Inflammation (AlSl) on All-cause, Cardiovascular Mortality and Cause-Specific Mortality in Adult Cancer Patients

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Authors

RSRuihong SunQLQingquan LuoMWMadison Wan

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Overview

Analysis using Cox proportional-hazards revealed AISI predicts all-cause and cardiovascular mortality in cancer patients, indicating systemic inflammation's role.

Key Points

  • Elevated quartiles of AISI are linked to increased all-cause mortality in cancer patients, suggesting systemic inflammation's significance.
  • With c-indices of 0.82 and 0.81, the predictive capability of AISI for mortality outcomes was notably high, underscoring its relevance.
  • Restricted cubic spline transformations were used to analyze the dose-response relationship between AISI and mortality, enhancing understanding of its implications.
  • Data from NHANES involving 2,253 subjects shows AISI could serve as a valuable prognostic marker for managing cancer patients.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c1954e9b7b07f3a0618a31https://doi.org/10.6913/mrhk.070303
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Also Consider

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  1. 1Association between AISI and mortality among individuals with abdominal obesity: A cohort study2026
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  3. 3Association of AISI and SIRI levels with mortality risk in patients with type 2 diabetes: A retrospective cohort study2026
  4. 4The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury2025 · 6 citations
  5. 5Admission systemic immune-inflammatory index predicts long-term mortality in patients with acute ischemic stroke: a retrospective analysis of the MIMIC-III database2026