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September 10, 2025Scientific ReportsOpen Access

The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury

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Authors

RLRuming LiuYFYunlong FanBJBo Jia

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Overview

Observational analysis shows higher mortality in patients with elevated AISI in sepsis-associated acute kidney injury, indicating its potential as a prognostic marker.

Key Points

  • Higher 30-/90-/180-day and 1-year mortality in sepsis-associated acute kidney injury patients with elevated AISI, indicating a significant risk factor for mortality.
  • The study included 9714 patients with sepsis-associated acute kidney injury, revealing a clear predictive relationship between AISI levels and mortality outcomes.
  • Cox proportional hazard regression and Kaplan-Meier analyses were used to assess the relationship between aggregate index of systemic inflammation and mortality rates.
  • Findings suggest that early identification of patients with high AISI may enable timely interventions to improve survival rates in sepsis-associated acute kidney injury.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1c64554b1d3bfb60f283dhttps://doi.org/10.1038/s41598-025-16081-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between the aggregate index of systemic inflammation and 28- or 365-day mortality in acute myocardial infarction patients: insights from the MIMIC-IV database2025
  2. 2Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study2024 · 5 citations
  3. 3Admission systemic immune-inflammatory index predicts long-term mortality in patients with acute ischemic stroke: a retrospective analysis of the MIMIC-III database2026
  4. 4Association of Aggregate Index of Systemic Inflammation (AISI) with all-cause mortality in critically Ill pediatric patients: a retrospective cohort study2026
  5. 5Systemic inflammatory dysregulation and short-term mortality in critically ill patients with sepsis and cirrhosis: incremental prognostic value of the aggregate index of systemic inflammation2026