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March 10, 2026Intensive Care Medicine ExperimentalOpen Access

Admission systemic immune-inflammatory index predicts long-term mortality in patients with acute ischemic stroke: a retrospective analysis of the MIMIC-III database

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Authors

XSXiao SuInner Mongolia Medical UniversityXTXiuqing TongInner Mongolia Medical UniversityNLNing LiInner Mongolia People's Hospital

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Implication

Retrospective analysis shows high systemic immune-inflammatory index predicts higher mortality in acute ischemic stroke, indicating its prognostic value.

Key Points

  • This study aims to evaluate the relationship between systemic immune-inflammatory indices and long-term mortality in acute ischemic stroke patients.
  • Conducted a retrospective cohort study using data from 1222 acute ischemic stroke patients in the MIMIC-III database.
  • Classified patients into tertiles based on AISI levels (low, medium, and high).
  • Utilized Cox proportional risk model for estimating relationships between AISI and all-cause mortality.
  • Performed restricted cubic spline and subgroup analyses for validation.
  • High AISI patients demonstrated a 31% increased risk of death after 90 days compared to low AISI patients.
  • Those with high AISI exhibited a 27% increased risk of mortality after 365 days.
  • There was a 30% increased risk of death after two years in high AISI patients compared to low AISI patients.
  • Mortality rates increased gradually with rising AISI values after 5841.5.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/69af959570916d39fea4d4dfhttps://doi.org/10.1186/s40635-026-00878-5
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