What does this research mean for the field?

Elevated levels of the aggregate index of systemic inflammation (AISI) are associated with increased 28-day and 90-day mortality in critically ill patients with sepsis and cirrhosis, offering complementary prognostic value to established clinical predictors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between the aggregate index of systemic inflammation (AISI) and short-term mortality, and assess its incremental value for clinical risk stratification in critically ill patients with sepsis and cirrhosis.

August 27, 2026BMC GastroenterologyOpen Access

Systemic inflammatory dysregulation and short-term mortality in critically ill patients with sepsis and cirrhosis: incremental prognostic value of the aggregate index of systemic inflammation

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Authors

YWYulan WangHong Kong Polytechnic University SYSong Yang XZXinyuan Zhang

Discussion

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Implication

Retrospective multicohort study reveals elevated aggregate index of systemic inflammation predicts mortality in sepsis with cirrhosis, highlighting complementary prognostic utility.

Key Points

To evaluate the association between the aggregate index of systemic inflammation (AISI) and short-term mortality, and assess its incremental value for clinical risk stratification in critically ill patients with sepsis and cirrhosis.
Conducted a retrospective multicohort study including 822 critically ill patients from the MIMIC-IV database (development cohort) and 374 patients from the eICU database (independent replication cohort).
Evaluated natural logarithm-transformed AISI (Ln AISI) as quartiles and continuous values against primary outcomes of 28-day and 90-day all-cause mortality.
Analyzed survival using Kaplan–Meier curves, multivariable Cox proportional-hazards models, restricted cubic splines, propensity-score matching, and decision-curve analysis.
Higher Ln AISI levels were significantly associated with higher 28-day and 90-day mortality across quartiles in both the MIMIC-IV and eICU cohorts (all P for trend < 0.001).
Kaplan–Meier survival probabilities were consistently lower in higher Ln AISI quartiles, and associations remained directionally consistent after propensity score matching.
Adding Ln AISI yielded limited improvements in discrimination but enhanced risk-reclassification metrics and decision-curve net benefit.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a8fea0d10c91c1e9262204a https://doi.org/10.1186/s12876-026-05271-w

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Implication

Retrospective multicohort study reveals elevated aggregate index of systemic inflammation predicts mortality in sepsis with cirrhosis, highlighting complementary prognostic utility.

Systemic inflammatory dysregulation and short-term mortality in critically ill patients with sepsis and cirrhosis: incremental prognostic value of the aggregate index of systemic inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

Systemic inflammatory dysregulation and short-term mortality in critically ill patients with sepsis and cirrhosis: incremental prognostic value of the aggregate index of systemic inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

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